| 세션명 | 대학원생 구두발표(코스맥스) |
|---|---|
| 발표장 | 제6회장 |
| 논문코드 | OC-7 |
| 발표일 | 2024-04-3 |
| 발표시간 | 16:45-17:00 |
| 논문제목 | Engineering polysaccharide for developing immune-activator vaccine platform |
| 발표자 | 문정현 |
| 발표자 소속 | 인하대학교 |
| 저자 | 문정현, 김유빈, 손세진† |
| 소속 | 인하대학교 |
| 논문초록 | Polysaccharides, recognized as pathogen-associated molecular patterns (PAMPs) by pattern recognition receptors (PRRs) in PAMP-PRR interaction, offer potential for immune regulation but face challenges due to low immunogenicity in immunoadjuvant applications. Prior study introduced core hollow mannan nanocapsule to enhance polysaccharide immunogenicity via multivalent PAMP-PRR interaction. This study aims to evaluate various polysaccharides immunogenicity by recognizing specific PRR on dendritic cell, using chemical modifications like oxidation, reduction, sulfation, phosphorylation, and carboxymethylation to increase complexity. We aim to compile a library facilitating immunomodulation and anticancer effects in cancer therapy, utilizing phosphorylation for antiviral effects in infectious diseases. This compiled library holds potential for precisely modulating immune responses across diseases including autoimmunity, gut microbiome modulation, inflammation, and infectious diseases. |
THE POLYMER SOCIETY OF KOREA